Type

Other / n/a

Authors

Fergal O'Brien
John P Gleeson
Hanne Jahns
Marie de Swarte
Wilfried Schneeweiss
Tanya J Levingstone
Florent David

Subjects

Veterinary

Topics
anatomy computed tomography follow up equine tissue engineering collagen based scaffolds mandibular aneurysmal bone cyst bone graft substitute

Enhanced bone healing using collagen-hydroxyapatite scaffold implantation in the treatment of a large multiloculated mandibular aneurysmal bone cyst in a thoroughbred filly. (2015)

Abstract An unmet need remains for a bone graft substitute material that is biocompatible, biodegradable and capable of promoting osteogenesis safely in vivo. The aim of this study was to investigate the use of a novel collagen-hydroxyapatite (CHA) bone graft substitute in the clinical treatment of a mandibular bone cyst in a young horse and to assess its potential to enhance repair of the affected bone. A 2 year-old thoroughbred filly, presenting with a multilobulated aneurysmal bone cyst, was treated using the CHA scaffold. Post-operative clinical follow-up was carried out at 2 weeks and 3, 6 and 14 months. Cortical thickening in the affected area was observed from computed tomography (CT) examination as early as 3 months post-surgery. At 14 months, reduced enlargement of the operated mandible was observed, with no fluid-filled area. The expansile cavity was occupied by moderately dense mineralized tissue and fat and the compact bone was remodelled, with a clearer definition between cortex and medulla observed. This report demonstrates the promotion of enhanced bone repair following application of the CHA scaffold material in this craniomaxillofacial indication, and thus the potential of this material for translation to human applications. Copyright © 2015 John Wiley & Sons, Ltd.
Collections Ireland -> Royal College of Surgeons in Ireland -> Anatomy Articles
Ireland -> Royal College of Surgeons in Ireland -> Department of Anatomy

Full list of authors on original publication

Fergal O'Brien, John P Gleeson, Hanne Jahns, Marie de Swarte, Wilfried Schneeweiss, Tanya J Levingstone, Florent David

Experts in our system

1
Fergal J O'Brien
Royal College of Surgeons in Ireland
Total Publications: 268
 
2
John P Gleeson
Royal College of Surgeons in Ireland
Total Publications: 26
 
3
Hanne Jahns
University College Dublin
Total Publications: 3
 
4
Marie de Swarte
University College Dublin
Total Publications: 3
 
5
Wilfried Schneeweiss
University College Dublin
Total Publications: 5
 
6
Tanya J Levingstone
Royal College of Surgeons in Ireland
Total Publications: 29
 
7
Florent David
University College Dublin
Total Publications: 16