Type

Other / n/a

Authors

Raymond L Stallings
Timothy A Chan
Armida WM Fabius
Berenice Ortiz
Jacqueline Ryan
Derek Murphy
Elisa Lazzari
Niamh Foley
Caroline A Jefferies
Niamh Moran
and 2 others

Subjects

Biochemistry

Topics
gene expression protein binding gene expression profiling aurora kinases neuroblastoma genetics mortality oncogene proteins genetics metabolism protein serine threonine kinases genetics metabolism enzyme stability aurora kinase a cell line tumor suppressor proteins genetics metabolism apoptosis genetics tyrosine metabolism class 2 genetics metabolism receptor like protein tyrosine phosphatases tumor humans phosphorylation life sciences

Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase a oncogene. (2012)

Abstract BACKGROUND: Protein tyrosine phosphatase receptor delta (PTPRD) is a member of a large family of protein tyrosine phosphatases which negatively regulate tyrosine phosphorylation. Neuroblastoma is a major childhood cancer arising from precursor cells of the sympathetic nervous system which is known to acquire deletions and alterations in the expression patterns of PTPRD, indicating a potential tumor suppressor function for this gene. The molecular mechanism, however, by which PTPRD renders a tumor suppressor effect in neuroblastoma is unknown.RESULTS: As a molecular mechanism, we demonstrate that PTPRD interacts with aurora kinase A (AURKA), an oncogenic protein that is over-expressed in multiple forms of cancer, including neuroblastoma. Ectopic up-regulation of PTPRD in neuroblastoma dephosphorylates tyrosine residues in AURKA resulting in a destabilization of this protein culminating in interfering with one of AURKA's primary functions in neuroblastoma, the stabilization of MYCN protein, the gene of which is amplified in approximately 25 to 30% of high risk neuroblastoma.CONCLUSIONS: PTPRD has a tumor suppressor function in neuroblastoma through AURKA dephosphorylation and destabilization and a downstream destabilization of MYCN protein, representing a novel mechanism for the function of PTPRD in neuroblastoma.
Collections Ireland -> Royal College of Surgeons in Ireland -> Department of Molecular and Cellular Therapeutics
Ireland -> Royal College of Surgeons in Ireland -> Molecular and Cellular Therapeutics Articles

Full list of authors on original publication

Raymond L Stallings, Timothy A Chan, Armida WM Fabius, Berenice Ortiz, Jacqueline Ryan, Derek Murphy, Elisa Lazzari, Niamh Foley, Caroline A Jefferies, Niamh Moran and 2 others

Experts in our system

1
Raymond L Stallings
Royal College of Surgeons in Ireland
Total Publications: 59
 
2
Caroline A Jefferies
Royal College of Surgeons in Ireland
Total Publications: 50
 
3
Niamh Moran
Royal College of Surgeons in Ireland
Total Publications: 50