Type

Other / n/a

Authors

John L Waddington
David Cotter
Joseph A Gogos
Maria Karayiorgou
David T Croke
Orna Tighe
Jeremiah J Clifford
Gerard J O'Sullivan
Colm M O'Tuathaigh
Daniela Babovic

Subjects

Psychology

Topics
phenotype psychophysiologic catechol o methyltransferase behavior male homozygote behavior animal knockout mice motor activity life sciences mice knockout analysis of variance animals habituation female exploratory behavior animal heterozygote habituation psychophysiologic

Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice. (2007)

Abstract Catechol-O-methyltransferase (COMT) inactivates dopamine in prefrontal cortex and is associated clinically with a schizophrenia endophenotype. Using an ethologically based approach, the phenotype of mice with heterozygous COMT deletion was characterised by decreased rearing with increased sifting and chewing. Heterozygous COMT deletion is associated with a distinctive phenotype. This differs from that which we have reported previously for heterozygous deletion of the schizophrenia risk gene neuregulin-1.
Collections Ireland -> Royal College of Surgeons in Ireland -> Department of Molecular and Cellular Therapeutics
Ireland -> Royal College of Surgeons in Ireland -> Molecular and Cellular Therapeutics Articles

Full list of authors on original publication

John L Waddington, David Cotter, Joseph A Gogos, Maria Karayiorgou, David T Croke, Orna Tighe, Jeremiah J Clifford, Gerard J O'Sullivan, Colm M O'Tuathaigh, Daniela Babovic

Experts in our system

1
John L Waddington
Royal College of Surgeons in Ireland
Total Publications: 170
 
2
David R Cotter
Royal College of Surgeons in Ireland
Total Publications: 56
 
3
Orna Tighe
Royal College of Surgeons in Ireland
Total Publications: 37
 
4
Gerard J O'Sullivan
Royal College of Surgeons in Ireland
Total Publications: 21
 
5
Colm M P O'Tuathaigh
University College Cork
Total Publications: 78