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Warren Thomas
Brian J Harvey
Arnold DK Hill
Leonie Young
Nina S McCarthy
Francesco Caiazza



medical sciences oligonucleotide array sequence analysis reverse transcriptase polymerase chain reaction rna medical molecular biology breast neoplasms cytosol humans cohort studies receptor epidermal growth factor antineoplastic agents receptor rna messenger epidermal growth factor female phospholipases a2 messenger antineoplastic agents hormonal prognosis hormonal

Cytosolic phospholipase A2-α expression in breast cancer is associated with EGFR expression and correlates with an adverse prognosis in luminal tumours. (2011)

Abstract BACKGROUND: The eicosanoid signalling pathway promotes the progression of malignancies through the production of proliferative prostaglandins (PGs). Cytosolic phospholipase A(2)α (cPLA(2)α) activity provides the substrate for cyclooxygenase-dependent PG release, and we have previously found that cPLA(2)α expression correlated with EGFR/HER2 over-expression in a small number of breast cancer cell lines.METHODS: The importance of differential cPLA(2)α activity in clinical breast cancer was established by relating the expression of cPLA(2)α in tissue samples from breast cancer patients, and two microarray-based gene expression datasets to different clinicopathological and therapeutic parameters.RESULTS: High cPLA(2)α mRNA expression correlated with clinical parameters of poor prognosis, which are characteristic of highly invasive tumours of the HER2-positive and basal-like subtype, including low oestrogen receptor expression and high EGFR expression. High cPLA(2)α expression decreased overall survival in patients with luminal cancers, and correlated with a reduced effect of tamoxifen treatment. The cPLA(2)α expression was an independent predictive parameter of poor response to endocrine therapy in the first 5 years of follow-up.CONCLUSION: This study shows a role of cPLA(2)α in luminal breast cancer progression, in which the enzyme could represent a novel therapeutic target and a predictive marker.
Collections Ireland -> Royal College of Surgeons in Ireland -> Molecular Medicine Articles
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Full list of authors on original publication

Warren Thomas, Brian J Harvey, Arnold DK Hill, Leonie Young, Nina S McCarthy, Francesco Caiazza

Experts in our system

Warren Thomas
Royal College of Surgeons in Ireland
Total Publications: 48
Brian J Harvey
Royal College of Surgeons in Ireland
Total Publications: 102
Arnold D K Hill
Royal College of Surgeons in Ireland
Total Publications: 110
Leonie S Young
Royal College of Surgeons in Ireland
Total Publications: 42