Type

Journal Article

Authors

John A Woolliams
Richard S Clifton-Hadley
Andy P Mitchell
Stephen C Bishop
Elizabeth J Glass
Sara H Downs
Mike Coffey
Isabella Higgins
Ian MS White
Donagh P. Berry
and 5 others

Subjects

Microbiology

Topics
irish population mycobacterium bovis bovine tuberculosis tb great britain irish great britain bovine tuberculosis genetic variation infection resistance holstein friesian sensitivity and specificity epidemiology britain and ireland

Evidence for genetic variance in resistance to tuberculosis in Great Britain and Irish Holstein-Friesian populations (2011)

Abstract Background: Here, we jointly summarise scientific evidence for genetic variation in resistance to infection with Mycobacterium bovis, the primary agent of bovine tuberculosis (TB), provided by two recent and separate studies of Holstein-Friesian dairy cow populations in Great Britain (GB) and Ireland. Methods: The studies quantified genetic variation within archived data from field and abattoir surveillance control programmes within each country. These data included results from the single intradermal comparative tuberculin test (SICTT), abattoir inspection for TB lesions and laboratory confirmation of disease status. Threshold animal models were used to estimate variance components for responsiveness to the SICTT and abattoir confirmed M. bovis infection. The link functions between the observed 0/1 scale and the liability scale were the complementary log-log in the GB, and logit link function in the Irish population. Results and discussion: The estimated heritability of susceptibility to TB, as judged by responsiveness to the SICTT, was 0.16 (0.012) and 0.14 (0.025) in the GB and Irish populations, respectively. For abattoir or laboratory confirmation of infection, estimates were 0.18 (0.044) and 0.18 (0.041) from the GB and the Irish populations, respectively. Conclusions: Estimates were all significantly different from zero and indicate that exploitable variation exists among GB and Irish Holstein Friesian dairy cows for resistance to TB. Epidemiological analysis suggests that factors such as variation in exposure or imperfect sensitivity and specificity would have resulted in underestimation of the true values.
Collections Ireland -> University College Dublin -> Veterinary Medicine Research Collection (superseded in 2015)
Ireland -> Teagasc -> Teagasc publications in Biomed Central
Ireland -> Teagasc -> Other Teagasc Research
Ireland -> University College Dublin -> Institutes and Centres
Ireland -> Teagasc -> Animal & Bioscience
Ireland -> University College Dublin -> College of Agriculture, Food Science and Veterinary Medicine (superseded in 2015)
Ireland -> University College Dublin -> School of Veterinary Medicine (superseded in 2015)
Ireland -> University College Dublin -> Centre for Veterinary Epidemiology and Risk Analysis (CVERA)
Ireland -> Teagasc -> Animal & Bioscience
Ireland -> Teagasc -> Animal & Grassland Research & Innovation Programme
Ireland -> University College Dublin -> CVERA Research Collection
Ireland -> Teagasc -> Other Teagasc Research
Ireland -> Teagasc -> Teagasc publications in Biomed Central
Ireland -> Teagasc -> Animal & Grassland Research & Innovation Programme

Full list of authors on original publication

John A Woolliams, Richard S Clifton-Hadley, Andy P Mitchell, Stephen C Bishop, Elizabeth J Glass, Sara H Downs, Mike Coffey, Isabella Higgins, Ian MS White, Donagh P. Berry and 5 others

Experts in our system

 
2
Isabella M. Higgins
Teagasc
Total Publications: 13
 
3
D P Berry
Teagasc
Total Publications: 215