Type

Journal Article

Authors

Ian H Robertson
Michael Gill
Mark A. Bellgrove
Ciara M. Greene

Subjects

Psychology

Topics
reaction time dopamine dbh sustained attention gene noradrenaline genotype balance

Noradrenergic genotype predicts lapses in sustained attention (2009)

Abstract Sustained attention is modulated by the neurotransmitter noradrenaline. The balance of dopamine and noradrenaline in the cortex is controlled by the DBH gene. The principal variant in this gene is a C/T change at position −1021, and the T allele at this locus is hypothesised to result in a slower rate of dopamine to noradrenaline conversion than the C allele. Two hundred participants who were genotyped for the DBH C−1021T marker performed the Sustained Attention to Response Task (SART). DBH genotype was found to significantly predict performance; participants with more copies of the T allele made more errors of commission, indicative of lapses in sustained attention. A significant negative correlation was also observed for all participants between errors of commission and mean reaction time. The decrease in noradrenaline occasioned by the T allele may impair sustained attention by reducing participants’ ability to remain alert throughout the task and by increasing their susceptibility to distractors.
Collections Ireland -> University College Dublin -> School of Psychology
Ireland -> University College Dublin -> College of Social Sciences and Law
Ireland -> University College Dublin -> Psychology Research Collection

Full list of authors on original publication

Ian H Robertson, Michael Gill, Mark A. Bellgrove, Ciara M. Greene

Experts in our system

1
Ian H Robertson
Trinity College Dublin
Total Publications: 142
 
2
Michael Gill
Trinity College Dublin
Total Publications: 260
 
3
Mark A. Bellgrove
Trinity College Dublin
Total Publications: 35
 
4
Ciara M. Greene
University College Dublin
Total Publications: 24