Journal Article


M. D. Gilchrist



central nervous system tissue damage linear acceleration iimpact biomechanics experimental device mathematical models brain injuries traumatic brain injury tbi

Experimental Device for Simulating Traumatic Brain Injury Resulting from Linear Accelerations (2004)

Abstract Various methods are used to model and analyse traumatic brain injuries (TBI) in the human.These include volunteer and cadaver experiments, anthropomorphic dummies, physicalmodels, computational models and mathematical models. The pathophysiological responseto mechanical impact of the human central nervous system and of in-vivo neural tissue ismost realistically analysed using animal models, which provide the best surrogate for thehuman brain. During non-fatal impacts, a mechanical insult may trigger a cascade ofphysiological processes, many mediated by neurochemicals within the neural tissue whichwill, in turn, control the depth and extent of the brain injury. This present paper reports thedevelopment of a novel experimental device which can apply different linear accelerationimpacts directly to in-vivo neural tissue in a manner which permits the experimental analysisof non-fatal TBI of varying severity.
Collections Ireland -> University College Dublin -> Mechanical & Materials Engineering Research Collection
Ireland -> University College Dublin -> College of Engineering & Architecture
Ireland -> University College Dublin -> School of Mechanical and Materials Engineering

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M. D. Gilchrist

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M. D. Gilchrist
University College Dublin
Total Publications: 172