Type

Journal Article

Authors

Denis P. Dowling
Mick Donegan

Subjects

Chemistry

Topics
ellipsometry protein adhesion plasma polymerization 1 protein ftir coatings atmospheric plasma proteins

Protein Adhesion on Atmospheric Plasma Deposited Quaternary Ammonium Salt Coatings (2013)

Abstract This study investigates protein adhesion on nm thick helium atmospheric plasma deposited quaternary ammonium salt (QAS) coatings. The adhesion of the proteins BSA, IgG and Fg was evaluated on coated and uncoated silicon wafer substrates. This study was carried out in PBS solution, under flow conditions using ellipsometry. The QAS was found to exhibit a low level of solubility in PBS over time (approx. 2 nm h−1). On addition of both the IgG and Fg proteins, it was found that a protective protein layer of 7 and 2 nm respectively was formed, which prevented further dissolution of the QAS. In contrast the 1 nm thick BSA protein layer, which formed on the QAS, was insufficiently thick to prevent the slow dissolution of the salt. It was concluded that the charge and structure of the protein influences its adhesion on the QAS surface.
Collections Ireland -> University College Dublin -> Mechanical & Materials Engineering Research Collection
Ireland -> University College Dublin -> College of Engineering & Architecture
Ireland -> University College Dublin -> School of Mechanical and Materials Engineering

Full list of authors on original publication

Denis P. Dowling, Mick Donegan

Experts in our system

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Denis P. Dowling
University College Dublin
Total Publications: 50