Type

Journal Article

Authors

Mark A Hollywood
Keith D. Thornbury
Noel G McHale
Gerard P Sergeant
Costin Camarasu
Tim I. Webb
Roddy J. Large
Adebola Morayo Akande
Subhrangsu Roy

Subjects

Biology

Topics
biology structure activity relationships channel novel the family relationships family structure group ion channels

Structure-Activity Relationships of a Novel Group of Large-Conductance Ca(2+) -Activated K(+) (BK) Channel Modulators: The GoSlo-SR Family. (2012)

Abstract Opening up ion channels: We synthesised a series of anthraquinone analogues, called the GoSlo-SR family. Their effects on bladder smooth muscle BK channels were examined and, as shown, shifted voltage dependent activation >-100 mV (at 10 μM). They were more efficacious than NS11021 and could provide a new scaffold for the design of efficacious BK openers.
Collections Ireland -> Dundalk IT -> Subject = Science
Ireland -> Dundalk IT -> Status = In Press
Ireland -> Dundalk IT -> Open Access DRIVERset
Ireland -> Dundalk IT -> Subject = Science: Biology
Ireland -> Dundalk IT -> Type = Article

Full list of authors on original publication

Mark A Hollywood, Keith D. Thornbury, Noel G McHale, Gerard P Sergeant, Costin Camarasu, Tim I. Webb, Roddy J. Large, Adebola Morayo Akande, Subhrangsu Roy

Experts in our system

1
Mark A Hollywood
Dundalk IT
Total Publications: 35
 
2
Keith D. Thornbury
Dundalk IT
Total Publications: 27
 
3
Noel G McHale
Dundalk IT
Total Publications: 35
 
4
Gerard P Sergeant
Dundalk IT
Total Publications: 24
 
5
Roddy J. Large
Royal College of Surgeons in Ireland
Total Publications: 4