Type

Journal Article

Authors

Noel G McHale
Keith D. Thornbury
Gerard P Sergeant
Mark A Hollywood

Subjects

Pharmacology

Topics
science cellular tool inhibitor plc signalling reliability smooth muscle cells

The PI-PLC inhibitor U-73122 is a potent inhibitor of the SERCA pump in smooth muscle (2010)

Abstract In this issue MacMillan & McCarron (2010) demonstrate that the PLC inhibitor U-73122 can potently inhibit Ca2+ release from isolated smooth muscle cells independent of its effect on PLC. Their data suggest that the PLC inhibitor can block the SERCA pump in smooth muscle and cast doubt on the reliability of U-73122 as the main pharmacological tool to assess the role of the PI-PLC pathway in cellular signalling.
Collections Ireland -> Dundalk IT -> Subject = Science
Ireland -> Dundalk IT -> Open Access DRIVERset
Ireland -> Dundalk IT -> Status = Published
Ireland -> Dundalk IT -> Type = Article

Full list of authors on original publication

Noel G McHale, Keith D. Thornbury, Gerard P Sergeant, Mark A Hollywood

Experts in our system

1
Noel G McHale
Dundalk IT
Total Publications: 35
 
2
Keith D. Thornbury
Dundalk IT
Total Publications: 27
 
3
Gerard P Sergeant
Dundalk IT
Total Publications: 24
 
4
Mark A Hollywood
Dundalk IT
Total Publications: 35