Type

Journal Article

Authors

Noel G McHale
Mark A Hollywood
Gerard P Sergeant

Subjects

Biochemistry

Topics
signalling science rabbits interstitial cells of cajal cells generation this review global

Ca 2+ signalling in urethral interstitial cells of Cajal (2006)

Abstract Interstitial cells of Cajal (ICC) in the urethra have been proposed as specialized pacemakers that are involved in the generation of urethral tone and therefore the maintenance of urinary continence. Recent studies on freshly dispersed ICC from the urethra of rabbits have demonstrated that pacemaker activity in urethra ICC is characterized by spontaneous transient depolarizations (STDs) under current clamp and spontaneous transient inward currents (STICs) under voltage clamp. When these events were simultaneously recorded with changes in intracellular Ca 2+ (using a Nipkow spinning disk confocal microscope) they were found to be associated with global Ca 2+ oscillations. In this short review we will consider some of these recent findings regarding the contribution of intracellular Ca 2+ stores and Ca 2+ influx to the generation of pacemaker activity in urethral ICC with particular emphasis on the contribution of reverse Na + /Ca 2+ exchange (NCX).
Collections Ireland -> Dundalk IT -> Subject = Science
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Ireland -> Dundalk IT -> Status = Published
Ireland -> Dundalk IT -> Type = Article

Full list of authors on original publication

Noel G McHale, Mark A Hollywood, Gerard P Sergeant

Experts in our system

1
Noel G McHale
Dundalk IT
Total Publications: 35
 
2
Mark A Hollywood
Dundalk IT
Total Publications: 35
 
3
Gerard P Sergeant
Dundalk IT
Total Publications: 24