Type

Journal Article

Authors

Colin Hill
Paul D. Cotter
R Paul Ross
Orla O'Sullivan
Alan J Marsh

Subjects

Microbiology

Topics
sequence alignment chemotherapeutic agents frequency analysis in silico analysis computational biology bacteria antimicrobial peptides molecular sequence data gene frequency sequence analysis dna operon type 1 genetic testing lantibiotic gene clusters genetic variation phylogeny bacteriocins peptides multigene family conserved sequence genes bacterial chemistry genetics amino acid sequence enzymology bacteria analysis

In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria (2010)

Abstract Background: Lantibiotics are lanthionine-containing, post-translationally modified antimicrobial peptides. These peptides have significant, but largely untapped, potential as preservatives and chemotherapeutic agents. Type 1 lantibiotics are those in which lanthionine residues are introduced into the structural peptide (LanA) through the activity of separate lanthionine dehydratase (LanB) and lanthionine synthetase (LanC) enzymes. Here we take advantage of the conserved nature of LanC enzymes to devise an in silico approach to identify potential lantibiotic-encoding gene clusters in genome sequenced bacteria. Results: In total 49 novel type 1 lantibiotic clusters were identified which unexpectedly were associated with species, genera and even phyla of bacteria which have not previously been associated with lantibiotic production. Conclusions: Multiple type 1 lantibiotic gene clusters were identified at a frequency that suggests that these antimicrobials are much more widespread than previously thought. These clusters represent a rich repository which can yield a large number of valuable novel antimicrobials and biosynthetic enzymes.
Collections Ireland -> Teagasc -> Food Biosciences
Ireland -> Teagasc -> Other Teagasc Research
Ireland -> Teagasc -> Teagasc publications in Biomed Central
Ireland -> Teagasc -> Food Programme

Full list of authors on original publication

Colin Hill, Paul D. Cotter, R Paul Ross, Orla O'Sullivan, Alan J Marsh

Experts in our system

1
Colin Hill
University College Cork
Total Publications: 351
 
2
Paul D. Cotter
Teagasc
Total Publications: 253
 
3
R Paul Ross
Teagasc
Total Publications: 441
 
4
Orla O'Sullivan
Teagasc
Total Publications: 92
 
5
Alan J Marsh
Teagasc