Type

Journal Article

Authors

Colin Hill
R Paul Ross
Catherine Stanton
Paul D. Cotter
Eileen F. O'Shea

Subjects

Veterinary

Topics
bacteriocin competitive advantage administration oral fatty acids gastrointestinal tract git probiotic bacteria pharmabiotic conjugated linoleic acid cla

Production of bioactive substances by intestinal bacteria as a basis for explaining probiotic mechanisms: Bacteriocins and conjugated linoleic acid (2012)

Abstract The mechanisms by which intestinal bacteria achieve their associated health benefits can be complex and multifaceted. In this respect, the diverse microbial composition of the human gastrointestinal tract (GIT) provides an almost unlimited potential source of bioactive substances (pharmabiotics) which can directly or indirectly affect human health. Bacteriocins and fatty acids are just two examples of pharmabiotic substances which may contribute to probiotic functionality within the mammalian GIT. Bacteriocin production is believed to confer producing strains with a competitive advantage within complex microbial environments as a consequence of their associated antimicrobial activity. This has the potential to enable the establishment and prevalence of producing strains as well as directly inhibiting pathogens within the GIT. Consequently, these antimicrobial peptides and the associated intestinal producing strains may be exploited to beneficially influence microbial populations. Intestinal bacteria are also known to produce a diverse array of health-promoting fatty acids. Indeed, certain strains of intestinal bifidobacteria have been shown to produce conjugated linoleic acid (CLA), a fatty acid which has been associated with a variety of systemic health-promoting effects. Recently, the ability to modulate the fatty acid composition of the liver and adipose tissue of the host upon oral administration of CLA-producing bifidobacteria and lactobacilli was demonstrated in a murine model. Importantly, this implies a potential therapeutic role for probiotics in the treatment of certain metabolic and immunoinflammatory disorders. Such examples serve to highlight the potential contribution of pharmabiotic production to probiotic functionality in relation to human health maintenance.
Collections Ireland -> Teagasc -> Food Biosciences
Ireland -> Teagasc -> Food Safety
Ireland -> Teagasc -> Food Programme

Full list of authors on original publication

Colin Hill, R Paul Ross, Catherine Stanton, Paul D. Cotter, Eileen F. O'Shea

Experts in our system

1
Colin Hill
University College Cork
Total Publications: 351
 
2
R Paul Ross
Teagasc
Total Publications: 441
 
3
Catherine Stanton
Teagasc
Total Publications: 261
 
4
Paul D. Cotter
Teagasc
Total Publications: 253
 
5
Eileen F. O'Shea
Teagasc
Total Publications: 10