Type

Journal Article

Authors

Peadar G Lawlor
Gillian E. Gardiner
Joseph P. Cassidy
Robert M. Kent
Mary C. Rea
Orla O'Donovan
Helen Hughes
Peter McLoughlin
Shiau Pin Tan
Laurie O'Sullivan
and 1 others

Subjects

Veterinary

Topics
combination diet administration oral e coli diarrhea pigs acid adverse effects dietary zinc oxide cereus var toyoi piglets body weight bacteria probiotocs bacillus pumilus escherichia coli

Evaluation of the Efficacy and Safety of a Marine-Derived Bacillus Strain for Use as an In-Feed Probiotic for Newly Weaned Pigs (2014)

Abstract Forty eight individual pigs (8.7±0.26 kg) weaned at 28±1 d of age were used in a 22-d study to evaluate the effect of oral administration of a Bacillus pumilus spore suspension on growth performance and health indicators. Treatments (n = 16) were: (1) non-medicated diet; (2) medicated diet with apramycin (200 mg/kg) and pharmacological levels of zinc oxide (2,500 mg zinc/kg) and (3) B. pumilus diet (non-medicated diet + 1010 spores/day B. pumilus). Final body weight and average daily gain tended to be lower (P = 0.07) and feed conversion ratio was worsened (P<0.05) for the medicated treatment compared to the B. pumilus treatment. Ileal E. coli counts were lower for the B. pumilus and medicated treatments compared to the non-medicated treatment (P<0.05), perhaps as a result of increased ileal propionic acid concentrations (P<0.001). However, the medicated treatment reduced fecal (P<0.001) and cecal (P<0.05) Lactobacillus counts and tended to reduce the total cecal short chain fatty acid (SCFA) concentration (P = 0.10). Liver weights were lighter and concentrations of liver enzymes higher (P<0.05) in pigs on the medicated treatment compared to those on the non-medicated or B. pumilus treatments. Pigs on the B. pumilus treatment had lower overall lymphocyte and higher granulocyte percentages (P<0.001) and higher numbers of jejunal goblet cells (P<0.01) than pigs on either of the other two treatments or the non-medicated treatment, respectively. However, histopathological examination of the small intestine, kidneys and liver revealed no abnormalities. Overall, the B. pumilus treatment decreased ileal E. coli counts in a manner similar to the medicated treatment but without the adverse effects on growth performance, Lactobacillus counts, cecal SCFA concentration and possible liver toxicity experienced with the medicated treatment.
Collections Ireland -> University College Cork -> APC Microbiome Institute
Ireland -> Teagasc -> Pig Development
Ireland -> University College Cork -> APC Microbiome Institute- Journal Articles
Ireland -> Teagasc -> Animal & Grassland Research & Innovation Programme
Ireland -> University College Cork -> Research Institutes and Centres

Full list of authors on original publication

Peadar G Lawlor, Gillian E. Gardiner, Joseph P. Cassidy, Robert M. Kent, Mary C. Rea, Orla O'Donovan, Helen Hughes, Peter McLoughlin, Shiau Pin Tan, Laurie O'Sullivan and 1 others

Experts in our system

2
Gillian E. Gardiner
Teagasc
Total Publications: 63
 
3
Joseph P. Cassidy
University College Dublin
Total Publications: 55
 
4
Robert M. Kent
Teagasc
Total Publications: 7
 
5
Mary C Rea
Teagasc
Total Publications: 87
 
6
Orla O'Donovan
Waterford Institute of Technology
Total Publications: 26
 
7
Helen Hughes
Waterford Institute of Technology
Total Publications: 23
 
8
Peter McLoughlin
Waterford Institute of Technology
Total Publications: 28
 
9
Shiau Pin Tan
Waterford Institute of Technology
Total Publications: 6
 
10
Laurie O'Sullivan
Teagasc
Total Publications: 14