Journal Article


Cliona O'Farrelly
Mario A. Fares
Andrew T. Lloyd
David J. Lynn



antimicrobial peptides biology mammalian defensins maximum likelihood family immune response sites

Evidence of Positively Selected Sites in Mammalian a-Defensins (2004)

Abstract Defensins are a family of mammalian antimicrobial peptides that exhibit variable activity against a panel of microbes,including bacteria, fungi, and enveloped viruses. We have employed a maximum-likelihood approach to detect evidenceof positive selection (adaptive evolution) in the evolution of these important molecules of the innate immune response.We have identified 14 amino acid sites that are predicted to be subject to positive selection. Furthermore, we show that all these sites are located in the mature antimicrobial peptide and not in the prepropeptide region of the molecule, implying that they are of functional importance. These results suggest that mammalian a-defensins have been under selective pressure to evolve in response to potentially infectious challenges by fast-evolving microbes.
Collections Ireland -> Maynooth University -> Subject = Science & Engineering: Biology
Ireland -> Maynooth University -> Subject = Science & Engineering
Ireland -> Maynooth University -> Type = Article
Ireland -> Maynooth University -> Status = Published
Ireland -> Maynooth University -> Open Access DRIVERset

Full list of authors on original publication

Cliona O'Farrelly, Mario A. Fares, Andrew T. Lloyd, David J. Lynn

Experts in our system

Cliona O'Farrelly
Trinity College Dublin
Total Publications: 126
Mario Ali Fares
Trinity College Dublin
Total Publications: 43
Andrew T. Lloyd
Trinity College Dublin
Total Publications: 17
David J Lynn
Total Publications: 36