Journal Article


Eladio Barrio
Andres Moya
Mario Ali Fares



maintenance bacterial evolution biology stability bacteria genetic drift transmission

GroEL and the maintenance of bacterial endosymbiosis (2004)

Abstract Many eukaryotic organisms have symbiotic associations with obligate intracellular bacteria. The clonal transmission of endosymbionts between host generations should lead to the irreversible fixation of slightly deleterious mutations in their non-recombinant genome by genetic drift. However, the stability of endosymbiosis indicates that some mechanism is involved in the amelioration of the effects of these mutations. We propose that the chaperone GroEL was involved in the acquisition of an endosymbiotic lifestyle not only by means of its over-production, as proposed by Moran, but also by its adaptive evolution mediated by positive selection to improve the interaction with the unstable endosymbiont proteome.
Collections Ireland -> Maynooth University -> Subject = Science & Engineering: Biology
Ireland -> Maynooth University -> Subject = Science & Engineering
Ireland -> Maynooth University -> Type = Article
Ireland -> Maynooth University -> Status = Published
Ireland -> Maynooth University -> Open Access DRIVERset

Full list of authors on original publication

Eladio Barrio, Andres Moya, Mario Ali Fares

Experts in our system

Mario Ali Fares
Trinity College Dublin
Total Publications: 43