Type

Journal Article

Authors

Bernard P. Mahon
Joseph P. Cassidy
Paul Corcoran
Claire Brady
Karen English

Subjects

Microbiology

Topics
expression il 10 asthma il 1 cell culture institute of immunology allergic nf b biology epithelial cells inflammation

Inflammation of the respiratory tract is associated with CCL28 and CCR10 expression in a murine model of allergic asthma (2006)

Abstract Mouse models and in vitro cell culture were used to examine airway expression of the mucosal chemokine CCL28. Low levels of constitutively expressed mRNA were observed in transformed murine epithelial cells, but high levels could be induced by stimulation. Cytokines that signalthrough NF-B, including IL-10 and TNF- or via JAK-STAT pathway including oncostatin M induced CCL28 in airway epithelial cells in vitro. Immunohistochemistry of murine airway tissue revealed that constitutive expression of CCL28 protein in vivo was low and not ubiquitous.However, abundant expression was detected in epithelia and lymphoid aggregates following allergic sensitization and challenge with ovalbumin. This was accompanied by increased detection of cells expressing CCR10 protein and mRNA in inflamed airways. Taken together, these data supporta role for CCL28 in contributing to allergen driven airway pathologies, show that proinflammatory cytokines can induce this signal and suggest a role for CCR10 expressing cells in airway inflammation.
Collections Ireland -> Maynooth University -> Academic Unit = Faculty of Science and Engineering: Research Institutes: Institute of Immunology
Ireland -> Maynooth University -> Subject = Science & Engineering: Biology
Ireland -> Maynooth University -> Subject = Science & Engineering
Ireland -> Maynooth University -> Academic Unit = Faculty of Science and Engineering: Biology
Ireland -> Maynooth University -> Academic Unit = Faculty of Science and Engineering: Research Institutes
Ireland -> Maynooth University -> Subject = Science & Engineering: Institute of Immunology
Ireland -> Maynooth University -> Type = Article
Ireland -> Maynooth University -> Academic Unit = Faculty of Science and Engineering
Ireland -> Maynooth University -> Status = Published
Ireland -> Maynooth University -> Open Access DRIVERset

Full list of authors on original publication

Bernard P. Mahon, Joseph P. Cassidy, Paul Corcoran, Claire Brady, Karen English

Experts in our system

1
Bernard P. Mahon
Maynooth University
Total Publications: 73
 
2
Joseph P. Cassidy
University College Dublin
Total Publications: 55
 
3
Karen English
Maynooth University
Total Publications: 37