Type

Journal Article

Authors

Linda Giblin
R Paul Ross
Tommie V McCarthy
Colin Hill
William Meaney
James Flynn
Katja Klostermann
Donagh P. Berry
Mairead Daly
Christine Beecher

Subjects

Microbiology

Topics
interleukin 8 lactococcus lactis cytology mastitis bovine cell count interleukin 1 il 1 milk interleukin 1beta somatic cell count mammary glands animal mastitis gene expression vaccination local administration female cattle prevention control genetics microbiology immunology animals probiotic treatment

Administration of a live culture of Lactococcus lactis DPC 3147 into the bovine mammary gland stimulates the local host immune response, particularly IL-1beta and IL-8 gene expression (2009)

Abstract Mastitis is one of the most costly diseases to the dairy farming industry. Conventional antibiotic therapy is often unsatisfactory for successful treatment of mastitis and alternative treatments are continually under investigation. We have previously demonstrated, in two separate field trials, that a probiotic culture, Lactococcus lactis DPC 3147, was comparable to antibiotic therapy to treat bovine mastitis. To understand the mode of action of this therapeutic, we looked at the detailed immune response of the host to delivery of this live strain directly into the mammary gland of six healthy dairy cows. All animals elicited signs of udder inflammation 7 h post infusion. At this time, clots were visible in the milk of all animals in the investigation. The most pronounced increase in immune gene expression was observed in Interleukin (IL)-1β and IL-8, with highest expression corresponding to peaks in somatic cell count. Infusion with a live culture of a Lc. lactis leads to a rapid and considerable innate immune response.
Collections Ireland -> University College Cork -> Research Institutes and Centres
Ireland -> University College Cork -> Biochemistry and Cell Biology
Ireland -> University College Cork -> Biochemistry and Cell Biology - Journal Articles
Ireland -> University College Cork -> Microbiology
Ireland -> University College Cork -> College of Science, Engineering and Food Science
Ireland -> University College Cork -> Alimentary Pharmabiotic Centre
Ireland -> University College Cork -> Microbiology - Journal Articles
Ireland -> University College Cork -> Alimentary Pharmabiotic Centre - Journal Articles

Full list of authors on original publication

Linda Giblin, R Paul Ross, Tommie V McCarthy, Colin Hill, William Meaney, James Flynn, Katja Klostermann, Donagh P. Berry, Mairead Daly, Christine Beecher

Experts in our system

1
Linda Giblin
Teagasc
Total Publications: 43
 
2
R Paul Ross
Teagasc
Total Publications: 441
 
3
Tommie V McCarthy
University College Cork
Total Publications: 24
 
4
Colin Hill
University College Cork
Total Publications: 351
 
5
James Flynn
Teagasc
Total Publications: 15
 
6
D P Berry
Teagasc
Total Publications: 200
 
7
Mairead Daly
Teagasc
Total Publications: 9
 
8
Christine Beecher
Teagasc
Total Publications: 7