Type

Journal Article

Authors

Cormac G. Gahan
Colin Hill
Roy D. Sleator
Debbie Watson

Subjects

Microbiology

Topics
administration dosage physiology probiotics bifidobacterium listeriosis lactococcus lactis nz9000 microbiology dna bacterial gastrointestinal delivery animals plasmids gastrointestinal transit mice transformation bacterial organisms genetically modified lactococcus lactis antibiosis bile protein listeria monocytogenes bacterial proteins feces electroporation bile female gastrointestinal bacteria genetics bile tolerance gastrointestinal tract microbial viability listeria monocytogenes mice inbred balb c bifidobacterium breve ucc2003 atp binding cassette transporters

Enhancing bile tolerance improves survival and persistence of Bifidobacterium and Lactococcus in the murine gastrointestinal tract (2008)

Abstract The majority of commensal gastrointestinal bacteria used as probiotics are highly adapted to the specialised environment of the large bowel. However, unlike pathogenic bacteria; they are often inadequately equipped to endure the physicochemical stresses of gastrointestinal (GI) delivery in the host. Herein we outline a patho-biotechnology strategy to improve gastric delivery and host adaptation of a probiotic strain Bifidobacterium breve UCC2003 and the generally regarded as safe (GRAS) organism Lactococcus lactis NZ9000.
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Full list of authors on original publication

Cormac G. Gahan, Colin Hill, Roy D. Sleator, Debbie Watson

Experts in our system

1
Cormac G M Gahan
University College Cork
Total Publications: 109
 
2
Colin Hill
University College Cork
Total Publications: 351
 
3
Roy D. Sleator
University College Cork
Total Publications: 44