Type

Journal Article

Authors

Dermot Brabazon
Stefan Lohfeld
Szilvia Eosoly

Subjects

Engineering

Topics
poly caprolactone hydroxyapatite hap materials bone scaffold selective laser sintering sls tissue engineering scaffolds mechanical engineering bone tissue engineering

Effect of hydroxyapatite on biodegradable scaffolds fabricated by SLS (2008)

Abstract Selective laser sintering (SLS) has the potential to fabricate bioresorbable polymer / ceramic composite scaffolds with pre-designed external and internal architecture that can be used for bone tissue engineering applications. Scaffolds were fabricated using poly-c-caprolactone as the base material. The effect of 15 and 30 wt% of hydroxyapatite (HA) addition was investigated in terms of compressive properties, accuracy, surface topology, and wettability. Fabricated dimensions of PCL microstructures showed great deviations from their nominal values. Average surface roughness was found to be Ra=25±4 gm. Increased HA content had no statistically significant effect on accuracy and surface roughness. However the addition of HA had a significant influence on compressive properties, hydrophobicity and wettability of the samples. Addition of 30 wt% HA improved initial compressive modulus of pure PCL scaffolds from 1.31±0.08 MPa to 1.58±0.18 MPa. Yield strength values increased from 0.14±0.07 MPa to 0.17±0.01 MPa by adding 15 wt% of HA, but decreased with further HA addition. Yield strain for all compositions was over c=0.06. Increased HA content decreased hydrophobicity and increased wettability of scaffold surfaces. The study demonstrated the ability of SLS to fabricate tissue engineering scaffolds, and the positive effect of HA particle reinforcement in terms of compressive mechanical properties and surface characteristics.
Collections Ireland -> Dublin City University -> Publication Type = Article
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools
Ireland -> Dublin City University -> Status = Published
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools: Faculty of Engineering and Computing: School of Mechanical and Manufacturing Engineering
Ireland -> Dublin City University -> Subject = Engineering: Mechanical engineering
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools: Faculty of Engineering and Computing
Ireland -> Dublin City University -> Subject = Engineering: Materials
Ireland -> Dublin City University -> Subject = Engineering

Full list of authors on original publication

Dermot Brabazon, Stefan Lohfeld, Szilvia Eosoly

Experts in our system

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Dermot Brabazon
Dublin City University
Total Publications: 162