Type

Journal Article

Authors

Dermot Brabazon
Marcin Lipowiecki

Subjects

Engineering

Topics
porosity mechanical engineering bone scaffold rapid prototyping mechanical properties bone morphogenetic proteins osteoconductivity materials

Design of bone scaffolds structures for rapid prototyping with increased strength and osteoconductivity (2009)

Abstract The geometry of bone scaffolds plays a crucial role in bone tissue regeneration. This architecture, especially pore size and shape, determines the mechanical strength of the scaffold. A number of previous workers have indicated the parameters which are believed to be the main stimulus in the adaptive bone remodelling process. An ideal bone manufacturing system would deliver bone morphogenetic proteins (BMP) and provide adequate mechanical properties. The aim of this study was to design a highly osteoconductive and mechanically strong bone regeneration scaffold which can be successfully manufactured. Three porous architectures of scaffold were designed using Solid Edge 3D solid modelling software. The equivalent trabecular structure model consisted of repea table unit cells arranged in layers to fill the chosen scaffold volume. The three different unit cell structures examined include cubic, triangular, and hexagonal polyhedral. Designed scaffold's pores were varied in this study to 120, 340 and 600m. This range was selected to meet one of the requirements of the scaffold design—the macropores must be at least 100m in diameter, so the cells can penetrate and proliferate within the structure. The strengths of each scaffold were determined using ANSYS finite element software. Trabecular scaffold designs were analysed independently and in connection with simulated cortical bone in order to investigate their stress-strain response. As well as providing useful information on strengths developed from these to pologies, the models developed indicated geometric constraints in order to tailor scaffolds to specific patient needs.
Collections Ireland -> Dublin City University -> Publication Type = Article
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools
Ireland -> Dublin City University -> Status = Published
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools: Faculty of Engineering and Computing: School of Mechanical and Manufacturing Engineering
Ireland -> Dublin City University -> Subject = Engineering: Mechanical engineering
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools: Faculty of Engineering and Computing
Ireland -> Dublin City University -> Subject = Engineering: Materials
Ireland -> Dublin City University -> Subject = Engineering

Full list of authors on original publication

Dermot Brabazon, Marcin Lipowiecki

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Dermot Brabazon
Dublin City University
Total Publications: 162