Type

Journal Article

Authors

Sumsun Naher
Dermot Brabazon
Tasneem Gul Kazi
Hassan Imran Afridi
Tasneem Gul Kazi

Subjects

Physics

Topics
chemically induced metals heavy smoking elements adult mechanical engineering humans scalp female chemistry toxicity rheumatoid arthritis inductive coupled plasma atomic emission spectrophotometer materials deficiency male hair mass spectrometry epidemiology trace elements adverse effects arthritis rheumatoid middle aged risk factors ireland spectrophotometry atomic rheumatoid arthritis ra cigarette smokers complications scalp hair

Association between essential trace and toxic elements in scalp hair samples of smokers rheumatoid arthritis subjects (2011)

Abstract The incidence of rheumatoid arthritis (RA) has been increased among people who possess habit of tobacco smoking. In the present study, zinc (Zn), copper (Cu), manganese (Mn), lead (Pb) and cadmium (Cd) were determined in scalp hair samples of smokers and nonsmokers RA patients, residents of Dublin, Ireland. For comparison purposes scalp hair samples of age and sex matched healthy smokers and nonsmokers were also analyzed. The concentrations of understudied elements were measured by inductive coupled plasma atomic emission spectrophotometer, prior to microwav e assisted acid digestion. The validity and accuracy of methodology was checked using certified reference material (NCS ZC 81002b) and by the conventional wet acid digestion method on the same certified reference material and on real samples. The mean hair Zn, Cu and Mn contents were significantly lower in smokers and nonsmokers RA patients as compared to healthy individuals (p = 0.01 - 0.001). Whereas the concentrations of Cd and Pb were significantly higher in scalp hair samples of RA patients of both group (p <0.001). The referent smokers have high level of Cd and Pb in their scalp hair samples as compared to those had not smoking tobacco (p <0.01). The ratio of Cd and Pb to Zn, Cu and Mn in scalp hair samples was also calculated. The Cd/Zn ratio was higher in smoker RA patients with related to nonsmoker RA and referents. This study is compelling evidence in support of positive associations between toxic elements, cigarette smoking, deficiency of essential trace elements and risk of arthritis.
Collections Ireland -> Dublin City University -> Publication Type = Article
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools
Ireland -> Dublin City University -> Status = Published
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools: Faculty of Engineering and Computing: School of Mechanical and Manufacturing Engineering
Ireland -> Dublin City University -> Subject = Engineering: Mechanical engineering
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools: Faculty of Engineering and Computing
Ireland -> Dublin City University -> Subject = Engineering: Materials
Ireland -> Dublin City University -> Subject = Engineering

Full list of authors on original publication

Sumsun Naher, Dermot Brabazon, Tasneem Gul Kazi, Hassan Imran Afridi, Tasneem Gul Kazi

Experts in our system

1
Sumsun Naher
Dublin City University
Total Publications: 56
 
2
Dermot Brabazon
Dublin City University
Total Publications: 162