Abstract In this work, various three-dimensional (3D) scaffolds were produced via microstereolithography (m-SLA) and 3D printing (3DP) techniques. This work demonstrates the advantages and disadvantages of these two different rapid prototyping methods for production of bone scaffolds. Compared to 3DP, SLA provides for smaller feature production with better dimensional resolution and accuracy. The permeability of these structures was evaluated experimentally and via numerical simulation utilizing a newly derived Kozeny– Carman based equation for intrinsic permeability. Both experimental and simulation studies took account of porosity percentage, pore size, and pore geometry. Porosity content was varied from 30% to 70%, pore size from 0.34 mm to 3 mm, and pore geometries of cubic and hexagonal closed packed were examined. Two different fluid viscosity levels of 1 mPas and 3.6 mPas were used. The experimental and theoretical results indicated that permeability increased when larger pore size, increased fluid viscosity, and higher percentage porosity were utilized, with highest to lowest degree of significance following the same order. Higher viscosity was found to result in permeabilities 2.2 to 3.3 times higher than for water. This latter result was found to be independent of pore morphology type. As well as demonstrating method for determining design parameters most beneficial for scaffold structure design, the results also illustrate how the variations in patient’s blood viscosity can be extremely important in allowing for permeability through the bone and scaffold structures.

Url http://doras.dcu.ie/20549/1/_Liopwiecki_JBM_A_2014_Permeability_of_RP_bone_scaffolds.pdf

Collections Ireland -> Dublin City University -> Publication Type = Article
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools
Ireland -> Dublin City University -> Status = Published
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools: Faculty of Engineering and Computing: School of Mechanical and Manufacturing Engineering
Ireland -> Dublin City University -> DCU Faculties and Centres = Research Initiatives and Centres: Advanced Processing Technology Research Centre (APTRC)
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools: Faculty of Engineering and Computing
Ireland -> Dublin City University -> Subject = Engineering
Ireland -> Dublin City University -> Subject = Engineering: Biomedical engineering
Ireland -> Dublin City University -> DCU Faculties and Centres = Research Initiatives and Centres
Ireland -> Dublin City University -> DCU Faculties and Centres = Research Initiatives and Centres: Irish Separation Science Cluster (ISSC)