Type

Journal Article

Authors

Tia E. Keyes
Niamh Moran
William Signac
Robert J. Forster
Marc Devocelle
Ute Neugebauer
Yann Pellegrin

Subjects

Chemistry

Topics
polypyridyl blood platelets multiple myeloma cell membrane conjugates membrane cell membrane permeability fluorescent dyes structure activity relationship diagnostic use tissue distribution oxygen cytoplasm pyridines humans metabolism cytology ruthenium cellular imaging organometallic compounds chemistry luminescent measurements molecular structure oligopeptides diagnosis pathology peptide

Ruthenium polypyridyl peptide conjugates: membrane permeable probes for cellular imaging (2008)

Abstract Two novel polyarginine labelled ruthenium polypyridyl dyes are reported, one conjugated to five, (Ru-Ahx-R5), and one to eight arginine residues, (Ru-Ahx-R8). Both complexes exhibit long-lived, intense, and oxygen sensitive luminescence. (Ru-R8) is passively, efficiently and very rapidly transported across the cell membrane into the cytoplasm without requirement for premeablisation of the cell membrane. Such ruthenium polypyridyl peptide conjugates open up the possibility for targeted cell delivery for environmentally sensitive intensity and lifetime imaging.
Collections Ireland -> Dublin City University -> Publication Type = Article
Ireland -> Dublin City University -> Subject = Physical Sciences: Chemistry
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools
Ireland -> Dublin City University -> Status = Published
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools: Faculty of Science and Health
Ireland -> Dublin City University -> DCU Faculties and Centres = Research Initiatives and Centres: Biomedical Diagnostics Institute (BDI)
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools: Faculty of Science and Health: School of Chemical Sciences
Ireland -> Dublin City University -> Subject = Physical Sciences
Ireland -> Dublin City University -> DCU Faculties and Centres = Research Initiatives and Centres: National Centre for Sensor Research (NCSR)
Ireland -> Dublin City University -> DCU Faculties and Centres = Research Initiatives and Centres

Full list of authors on original publication

Tia E. Keyes, Niamh Moran, William Signac, Robert J. Forster, Marc Devocelle, Ute Neugebauer, Yann Pellegrin

Experts in our system

1
Tia E. Keyes
Dublin City University
Total Publications: 104
 
2
Niamh Moran
Royal College of Surgeons in Ireland
Total Publications: 50
 
3
Robert J. Forster
Dublin City University
Total Publications: 92
 
4
Marc Devocelle
Royal College of Surgeons in Ireland
Total Publications: 65