Type

Journal Article

Authors

Lorraine O'Driscoll
Martin Clynes
John Crown
Giuseppe Gullo
Wei Ooi
Jo Ballot
Lisa Connolly
Susan Kennedy
Anne-Marie Larkin
Naomi Walsh

Subjects

Veterinary

Topics
mdr1 p glycoprotein mrp 1 multidrug resistance p gp immunohistochemistry cancer renal cell carcinoma multi drug resistance protein 1

Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal carcinoma (2009)

Abstract Background: Renal cancer patients respond poorly to conventional chemotherapy, this unresponsiveness may be attributable to multidrug resistance (MDR). The mechanisms of MDR in renal cancer are not fully understood and the specific contribution of ABC transporter proteins which have been implicated in the chemoresistance of various cancers has not been fully defined in this disease. Methods: The aim of this prospective study was to analyse by immunohistochemistry the expression of two of these transporter efflux pumps, namely MDR-1/P-gp (ABCB1) and MRP-1 (ABCC1) in archival material from 113 renal carcinoma patients. Results: In the largest study of its kind, results presented here show 100% of cases stained positively for P-gp and MRP-1 protein expression. Conclusion: However, although these findings do not prove a causal role, the high frequency of tumours expressing these efflux pumps suggests that they may be important contributors to the chemoresistance of this tumour type.
Collections Ireland -> Dublin City University -> Subject = Medical Sciences: Cancer
Ireland -> Dublin City University -> Publication Type = Article
Ireland -> Dublin City University -> Status = Published
Ireland -> Dublin City University -> Subject = Medical Sciences
Ireland -> Dublin City University -> DCU Faculties and Centres = Research Initiatives and Centres: National Institute for Cellular Biotechnology (NICB)
Ireland -> Dublin City University -> DCU Faculties and Centres = Research Initiatives and Centres

Full list of authors on original publication

Lorraine O'Driscoll, Martin Clynes, John Crown, Giuseppe Gullo, Wei Ooi, Jo Ballot, Lisa Connolly, Susan Kennedy, Anne-Marie Larkin, Naomi Walsh

Experts in our system

1
Lorraine O'Driscoll
Trinity College Dublin
Total Publications: 152
 
2
Martin Clynes
Dublin City University
Total Publications: 209
 
3
John Crown
Dublin City University
 
4
Susan Kennedy
Dublin City University
Total Publications: 37
 
5
Anne-Marie Larkin
Dublin City University
Total Publications: 6
 
6
Naomi Walsh
Dublin City University
Total Publications: 18