Type

Journal Article

Authors

Martin Clynes
Paul Dowling
Paul Neary
Pavel Vodicka
Miroslav Levy
Alessio Naccarati
Barbara Pardini
David J Hughes
Stephen F Madden
Sinéad T Aherne

Subjects

Medicine & Nursing

Topics
plasma groups mirnas patients early detection cell free colorectal cancer progression

Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression. (2014)

Abstract Screening for the early detection of colorectal cancer is important to improve patient survival. The aim of this study was to investigate the potential of circulating cell-free miRNAs as biomarkers of CRC, and their efficiency at delineating patients with polyps and benign adenomas from normal and cancer patient groups. The expression of 667 miRNAs was assessed in a discovery set of 48 plasma samples comprising normal, polyp, adenoma, and early and advanced cancer samples. Three miRNAs (miR-34a, miR-150, and miR-923) were further examined in a validation cohort of 97 subjects divided into the same five groups, and in an independent public dataset of 40 CRC samples and paired normal tissues. High levels of circulating miR-34a and low miR-150 levels distinguished groups of patients with polyps from those with advanced cancer (AUC = 0.904), and low circulating miR-150 levels separated patients with adenomas from those with advanced cancer (AUC = 0.875). In addition, the altered expression of miR-34a and miR-150 in an independent public dataset of forty CRC samples and paired normal tissues was confirmed. We identified two circulating miRNAs capable of distinguishing patient groups with different diseases of the colon from each other, and patients with advanced cancer from benign disease groups.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Martin Clynes, Paul Dowling, Paul Neary, Pavel Vodicka, Miroslav Levy, Alessio Naccarati, Barbara Pardini, David J Hughes, Stephen F Madden, Sinéad T Aherne

Experts in our system

1
Martin Clynes
Dublin City University
Total Publications: 209
 
2
Paul Dowling
Dublin City University
Total Publications: 79
 
3
Paul C Neary
IT Tallaght
Total Publications: 62
 
4
Pavel Vodicka
Royal College of Surgeons in Ireland
Total Publications: 4
 
5
Alessio Naccarati
Royal College of Surgeons in Ireland
Total Publications: 6
 
6
David J Hughes
Royal College of Surgeons in Ireland
Total Publications: 20
 
7
Stephen F Madden
Dublin City University
Total Publications: 42
 
8
Sinéad T Aherne
Dublin City University
Total Publications: 17