Type

Journal Article

Authors

Annemarie Larkin
Martin Clynes
Andrew McCann
Helena Joyce

Subjects

Pharmacology

Topics
this review cell membranes atp binding cassette transporters chemotherapeutic drugs expert opinion disease progression multidrug resistance anticancer drugs

Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism. (2015)

Abstract Chemotherapy involving the use of anticancer drugs remains an important strategy in the overall management of patients with metastatic cancer. Acquisition of multidrug resistance remains a major impediment to successful chemotherapy. Drug transporters in cell membranes and intracellular drug metabolizing enzymes contribute to the resistance phenotype and determine the pharmacokinetics of anticancer drugs in the body. Areas covered: ATP-binding cassette (ABC) transporters mediate the transport of endogenous metabolites and xenobiotics including cytotoxic drugs out of cells. Solute carrier (SLC) transporters mediate the influx of cytotoxic drugs into cells. This review focuses on the substrate interaction of these transporters, on their biology and what role they play together with drug metabolizing enzymes in eliminating therapeutic drugs from cells. Expert opinion: The majority of anticancer drugs are substrates for the ABC transporter and SLC transporter families. Together, these proteins have the ability to control the influx and the efflux of structurally unrelated chemotherapeutic drugs, thereby modulating the intracellular drug concentration. These interactions have important clinical implications for chemotherapy because ultimately they determine therapeutic efficacy, disease progression/relapse and the success or failure of patient treatment.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Annemarie Larkin, Martin Clynes, Andrew McCann, Helena Joyce

Experts in our system

1
Annemarie Larkin
Dublin City University
Total Publications: 25
 
2
Martin Clynes
Dublin City University
Total Publications: 209
 
3
Helena Joyce
Dublin City University
Total Publications: 10