Type

Journal Article

Authors

Martin Clynes
Paul Neary
Pavel Vodicka
Miroslav Levy
Alessio Naccarati
Barbara Pardini
Vincent Lynch
Paula Meleady
Michael Henry
Justine Meiller
and 3 others

Subjects

Medicine & Nursing

Topics
14 3 3 proteins cancer patients cancer cells pyruvate kinase colorectal cancer kinase 3 mass spectrometry colorectal cancer crc

Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer. (2014)

Abstract Colorectal cancer (CRC), a heterogeneous disease that is common in both men and women, continues to be one of the predominant cancers worldwide. Lifestyle, diet, environmental factors and gene defects all contribute towards CRC development risk. Therefore, the identification of novel biomarkers to aid in the management of CRC is crucial. The aim of the present study was to identify candidate biomarkers for CRC, and to develop a better understanding of their role in tumourogenesis. In this study, both plasma and tissue samples from patients diagnosed with CRC, together with non-malignant and normal controls were examined using mass spectrometry based proteomics and metabolomics approaches. It was established that the level of several biomolecules, including serotonin, gamma enolase, pyruvate kinase and members of the 14-3-3 family of proteins, showed statistically significant changes when comparing malignant versus non-malignant patient samples, with a distinct pattern emerging mirroring cancer cell energy production. The diagnosis and management of CRC could be enhanced by the discovery and validation of new candidate biomarkers, as found in this study, aimed at facilitating early detection and/or patient stratification together with providing information on the complex behaviour of cancer cells.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Martin Clynes, Paul Neary, Pavel Vodicka, Miroslav Levy, Alessio Naccarati, Barbara Pardini, Vincent Lynch, Paula Meleady, Michael Henry, Justine Meiller and 3 others

Experts in our system

1
Martin Clynes
Dublin City University
Total Publications: 209
 
2
Paul C Neary
IT Tallaght
Total Publications: 62
 
3
Pavel Vodicka
Royal College of Surgeons in Ireland
Total Publications: 4
 
4
Alessio Naccarati
Royal College of Surgeons in Ireland
Total Publications: 6
 
5
Vincent Lynch
Dublin City University
Total Publications: 10
 
6
Paula Meleady
Dublin City University
Total Publications: 95
 
7
Michael Henry
Dublin City University
Total Publications: 78
 
8
Justine Meiller
Dublin City University
Total Publications: 7