Type

Journal Article

Authors

Peter O'Gorman
Martin Clynes
Paul Dowling
Jennifer J Brady
Abdul Hameed

Subjects

Psychiatry

Topics
disease management this review multiple myeloma management treatment factor kappa b pathophysiology bone

Bone disease in multiple myeloma: pathophysiology and management. (2014)

Abstract Myeloma bone disease (MBD) is a devastating complication of multiple myeloma (MM). More than 80% of MM patients suffer from destructive bony lesions, leading to pain, fractures, mobility issues, and neurological deficits. MBD is not only a main cause of disability and morbidity in MM patients but also increases the cost of management. Bone destruction and lack of bone formation are main factors in the development of MBD. Some novel factors are found to be involved in the pathogenesis of MBD, eg, receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG) system (RANKL/OPG), Wingless (Wnt), dickkopf-1 (Wnt/DKK1) pathway. The addition of novel agents in the treatment of MM, use of bisphosphonates and other supportive modalities such as radiotherapy, vertebroplasty/kyphoplasty, and surgical interventions, all have significant roles in the treatment of MBD. This review provides an overview on the pathophysiology and management of MBD.
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Full list of authors on original publication

Peter O'Gorman, Martin Clynes, Paul Dowling, Jennifer J Brady, Abdul Hameed

Experts in our system

1
Peter O'Gorman
Dublin City University
Total Publications: 15
 
2
Martin Clynes
Dublin City University
Total Publications: 209
 
3
Paul Dowling
Dublin City University
Total Publications: 79