Type

Journal Article

Authors

Dermot Kenny
Bryan T Hennessy
John O'Leary
Oscar S Breathnach
Liam Grogan
Siobhan McFadden
Karl Egan
Niamh M Cooke

Subjects

Medicine & Nursing

Topics
female complications neoplasm staging platelet count thrombocytosis pathology blood etiology platelet activation male neoplasm metastasis humans middle aged aged platelet aggregation neoplasms

Increased platelet reactivity in patients with late-stage metastatic cancer. (2013)

Abstract Platelet hyperreactivity is associated with an increased risk of thrombosis. Cancer patients are at an increased risk of thrombosis, a risk that increases with disease progression. While cancer patients show evidence of platelet activation in vivo, few studies have extensively assessed whether these patients display platelet hyperreactivity. We hypothesized that patients with metastatic cancer would display platelet hyperreactivity, reflecting their associated high risk of thrombosis. In a cohort of patients with metastatic cancer (n = 13), we assessed platelet function using well-established assays of platelet reactivity (agonist-induced platelet aggregation, spontaneous platelet aggregation, and agonist-induced P-selectin expression). In comparison with healthy controls (n = 10), patients with metastatic cancer displayed global platelet hyperreactivity. Agonist-induced platelet aggregation responses to ADP (adenosine diphosphate), epinephrine, collagen, arachidonic acid, and PAR-1 (protease-activated receptor-1) activating peptide, as well as spontaneous platelet aggregation, were significantly increased in patients with metastatic cancer. Furthermore, agonist-induced platelet P-selectin expression was also significantly increased within the patient cohort. We demonstrate that patients with metastatic cancer are characterized by global platelet hyperreactivity, a factor that may contribute to their increased risk of thrombosis.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Dermot Kenny, Bryan T Hennessy, John O'Leary, Oscar S Breathnach, Liam Grogan, Siobhan McFadden, Karl Egan, Niamh M Cooke

Experts in our system

1
Dermot Kenny
Royal College of Surgeons in Ireland
 
2
Bryan T Hennessy
Royal College of Surgeons in Ireland
Total Publications: 33
 
3
John O'Leary
Trinity College Dublin
Total Publications: 93
 
4
Karl Egan
Royal College of Surgeons in Ireland