Type

Journal Article

Authors

Colette McDonagh
Richard O'Kennedy
Conor Byrne
Shibsekhar Roy
Chandra K Dixit

Subjects

Microbiology

Topics
antibodies nanoparticles animals blood platelets platelet membrane glycoprotein iib cattle chemistry metabolism humans combinatorial chemistry techniques

A chemical quenching- and physical blocking-based method to minimize process-mediated aggregation of antibody-crosslinked nanoparticles for imaging application. (2013)

Abstract Critical limitation of nanoparticles (NP) is their aggregation after functionalisation and antibody cross-linking. We analysed the cause of this aggregation with respect to functionalities (carboxyls and amines) on the NP surface. We have devised a low cost novel method to reduce such aggregations during protein cross-linking and validated it by probing the platelet surface with platelet surface-specific anti-CD41 antibody conjugated NPs.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Colette McDonagh, Richard O'Kennedy, Conor Byrne, Shibsekhar Roy, Chandra K Dixit

Experts in our system

1
Colette McDonagh
Dublin City University
Total Publications: 47
 
2
R O'Kennedy
Dublin City University
Total Publications: 197
 
3
Conor Byrne
Dublin City University
Total Publications: 18