Journal Article


Colette McDonagh
Richard O'Kennedy
Robert Woolley
Chandra K Dixit
Shibsekhar Roy



gold nanoparticles surface properties coloring agents gold nanoparticles chemistry particle size silicon dioxide

Synthesis and characterization of a Noble metal Enhanced Optical Nanohybrid (NEON): a high brightness detection platform based on a dye-doped silica nanoparticle. (2012)

Abstract A highly bright and photostable, fluorescent nanohybrid particle is presented which consists of gold nanoparticles (GNPs) embedded in dye-doped silica in a core-shell configuration. The dye used is the near-infrared emitting 4,5-benzo-5'-(iodoacetaminomethyl)-1',3,3,3',3'-pentamethyl-1-(4-sulfobutyl) indodicarbo cyanine. The nanohybrid architecture comprises a GNP core which is separated from a layer of dye molecules by a 15 nm buffer layer and has an outer protective, undoped silica shell. Using this architecture, a brightness factor of 550 has been achieved compared to the free dye. This hybrid system, referred to as Noble metal Enhanced Optical Nanohybrid (NEON) in this paper, is the first nanohybrid construct to our knowledge which demonstrates such tunable fluorescence property. NEON has enhanced photostability compared to the free dye and compared to a control particle without GNPs. Furthermore, the NEON particle, when used as a fluorescent label in a model bioassay, shows improved performance over assays using a conventional single dye molecule label.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Colette McDonagh, Richard O'Kennedy, Robert Woolley, Chandra K Dixit, Shibsekhar Roy

Experts in our system

Colette McDonagh
Dublin City University
Total Publications: 47
R O'Kennedy
Dublin City University
Total Publications: 197