Type

Journal Article

Authors

Martin Clynes
Michael Henry
Paula Meleady
Paul Dowling

Subjects

Microbiology

Topics
humans proteomics molecular weight isotope labeling proteome molecular sequence data amino acid sequence chromatography liquid chemistry mass spectrometry

Recent advances in clinical proteomics using mass spectrometry. (2010)

Abstract The ultimate objective of clinical proteomics is the successful discovery, validation and translation of biomarkers, together with new therapeutic targets into medical practices. New highly developed technologies in proteomics and their use in understanding tumor biology have significant clinical potential in the diagnosis, prognosis and treatment of disease. Areas such as MS, new labeling technologies and advancements in bioinformatics systems are now used to successfully detect disease-associated biomarkers together with therapeutic targets in complex biological specimens, including biofluids, cell lysates and tissue biopsies. Recent improvements in sample preparation (specifically focused on fractionation and enrichment) are enabling the analysis of low-abundance proteins together with many types of post-translational modifications. Targeted proteomic diagnostics will play a significant role in the development of personalized molecular medicine, a process that will be vital in modernizing healthcare structures.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Martin Clynes, Michael Henry, Paula Meleady, Paul Dowling

Experts in our system

1
Martin Clynes
Dublin City University
Total Publications: 209
 
2
Michael Henry
Dublin City University
Total Publications: 78
 
3
Paula Meleady
Dublin City University
Total Publications: 95
 
4
Paul Dowling
Dublin City University
Total Publications: 79