Type

Journal Article

Authors

Richard O'Kennedy
Barry Byrne
B Vijayalakshmi Ayyar
Paul J Conroy
Stephen Hearty

Subjects

Microbiology

Topics
humans vaccines hiv envelope protein gp41 malaria vaccines cancer vaccines aids vaccines immunology influenza vaccines binding sites surface plasmon resonance animals high throughput screening assays hiv envelope protein gp120

Surface plasmon resonance for vaccine design and efficacy studies: recent applications and future trends. (2010)

Abstract The lack of a clear correlation between design and protection continues to present a barrier to progress in vaccine research. In this article, we outline how surface plasmon resonance (SPR) biosensors are emerging as tools to help resolve some of the key biophysical determinants of protection and, thereby, facilitate more rational vaccine design campaigns. SPR technology has contributed significantly to our understanding of the complex biophysical determinants of HIV neutralization and offers a platform for preclinical evaluation of vaccine candidates. In particular, the concept of reverse-engineering HIV vaccine targets based on known broadly neutralizing antibody modalities is explored and extended to include other infectious diseases, such as malaria and influenza, and other diseases such as cancer. The analytical capacity afforded by SPR includes serum screening to monitor immune responses and highly efficient quality-control surveillance measures. These are discussed alongside key technological advances, such as developments in sample throughput, and a perspective predicting continued growth and diversification of the role of SPR in vaccine development is proposed.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Richard O'Kennedy, Barry Byrne, B Vijayalakshmi Ayyar, Paul J Conroy, Stephen Hearty

Experts in our system

1
R O'Kennedy
Dublin City University
Total Publications: 197
 
2
Barry Byrne
Dublin City University
Total Publications: 15
 
3
B Vijayalakshmi Ayyar
Dublin City University
Total Publications: 7
 
4
Paul J Conroy
Dublin City University
Total Publications: 9
 
5
Stephen Hearty
Dublin City University
Total Publications: 27