Journal Article


M Clynes
K Scanlon
A Howlett
R Nicamhlaoibh
C Daly
D Byrne



anti cancer drugs chemotherapy combination programmed cell death ribozymes cell apoptosis human cancers drug use drug resistance

Use of ribozymes and antisense oligodeoxynucleotides to investigate mechanisms of drug resistance. (1998)

Abstract Chemotherapy can cure a number of human cancers but resistance (either intrinsic or acquired) remains a significant problem in many patients and in many types of solid tumour. Combination chemotherapy (using drugs with different cellular targets/mechanisms) was introduced in order to kill cells which had developed resistance to a specific drug, and to allow delivery of a greater total dose of anti-cancer chemicals by combining drugs with different side-effects (Pratt et al., 1994). Nearly all anti-cancer drugs kill tumour cells by activating an endogenous bio-chemical pathway for cell suicide, known as programmed cell death or apoptosis.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

M Clynes, K Scanlon, A Howlett, R Nicamhlaoibh, C Daly, D Byrne

Experts in our system

Martin Clynes
Dublin City University
Total Publications: 209
C Daly
Trinity College Dublin
Total Publications: 15