Journal Article


Martin Clynes
Naomi Walsh
Paul Dowling



membrane proteins neoplasm invasiveness cancer metastasis cancer patients cancer invasion invasive cells metabolism humans cell invasion neoplasm proteins neoplasms cancer cells animals knowledge base proteomics pathology integrins

Membrane and membrane-associated proteins involved in the aggressive phenotype displayed by highly invasive cancer cells. (2008)

Abstract Invasion, the penetration of tumour cells into adjacent tissues, is a fundamental characteristic of malignant carcinomas and a first step in the metastatic process. The molecular mechanisms involved in tumour cell invasion are complex, but over the last couple of decades the knowledge base has grown quite considerably and many proteins with important roles in invasion have been identified and characterised. Benign tumours typically are encapsulated, which inhibits their ability to behave in a malignant manner, meaning these tumours do not grow in a location-limited less aggressive manner, do not invade surrounding tissues and do not metastasise. The ability of malignant tumours to invade and metastasise is the major cause of death for cancer patients. A greater insight into the molecular basis of cancer invasion and metastasis will lead to the development of novel therapies and specific panels of biomarkers for use in the treatment and diagnosis/monitoring in many types of metastatic cancer.
Collections Ireland -> Maynooth University -> Academic Unit = Faculty of Science and Engineering: Biology
Ireland -> Maynooth University -> Type = Article
Ireland -> Dublin City University -> PubMed
Ireland -> Maynooth University -> Academic Unit = Faculty of Science and Engineering
Ireland -> Maynooth University -> Status = Published
Ireland -> Maynooth University -> Open Access DRIVERset

Full list of authors on original publication

Martin Clynes, Naomi Walsh, Paul Dowling

Experts in our system

Martin Clynes
Dublin City University
Total Publications: 209
Naomi Walsh
Dublin City University
Total Publications: 18
Paul Dowling
Dublin City University
Total Publications: 79