Type

Journal Article

Authors

Norma O'Donovan
Martin Clynes
Alex J Eustace
Dermot O'Sullivan
Sharon A Glynn

Subjects

Pharmacology

Topics
lovastatin lung neoplasms mevastatin simvastatin neoplasm invasiveness humans pharmacology female therapeutic use drug effects analogs derivatives apoptosis cell line tumor breast neoplasms cell proliferation drug therapy cell adhesion male skin neoplasms pathology cell movement melanoma hydroxymethylglutaryl coa reductase inhibitors

The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells. (2007)

Abstract A number of recent studies have suggested that cancer incidence rates may be lower in patients receiving statin treatment for hypercholesterolemia. We examined the effects of statin drugs on in vitro proliferation, migration and invasion of melanoma cells. The ability of lovastatin, mevastatin and simvastatin to inhibit the melanoma cell proliferation was examined using cytotoxicity and apoptosis assays. Effects on cell migration and invasion were assessed using transwell invasion and migration chambers. Hypothesis testing was performed using 1-way ANOVA, and Student's t-test. Lovastatin, mevastatin and simvastatin inhibited the growth, cell migration and invasion of HT144, M14 and SK-MEL-28 melanoma cells. The concentrations required to inhibit proliferation of melanoma cells (0.8-2.1 microave previously been achieved in a phase I clinical trial of lovastatin in patients with solid tumours, (45 mg/kg/day resulted in peak plasma concentrations of approximately 3.9 micro Our results suggest that statin treatment is unlikely to prevent melanoma development at standard doses. However, higher doses of statins may have a role to play in adjuvant therapy by inhibiting growth and invasion of melanoma cells.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Norma O'Donovan, Martin Clynes, Alex J Eustace, Dermot O'Sullivan, Sharon A Glynn

Experts in our system

1
Norma O'Donovan
Dublin City University
Total Publications: 52
 
2
Martin Clynes
Dublin City University
Total Publications: 209
 
3
Alex J Eustace
Royal College of Surgeons in Ireland
Total Publications: 23
 
4
Dermot O'Sullivan
Dublin City University
 
5
Sharon A Glynn
National University of Ireland Galway
Total Publications: 21