Type

Journal Article

Authors

S Kennedy
J Crown
M Clynes
R O'Connor
G Gullo
W S Ooi
J Ballot
A Larkin
N Walsh
L O'Driscoll

Subjects

Biochemistry

Topics
mrp 1 immunohistochemistry adenocarcinoma pancreatic neoplasms cholangiocarcinoma carcinoma carcinoma neuroendocrine metabolism multidrug resistance associated proteins mdr1 p glycoprotein pancreatic multidrug resistance associated protein 1 efflux pumps aged drug biosynthesis p glycoprotein humans adult middle aged

MDR1/P-glycoprotein and MRP-1 drug efflux pumps in pancreatic carcinoma. (2007)

Abstract Pancreatic cancer is one of the most challenging solid organ malignancies. This is due to its aggressiveness, frequent late presentation as advanced disease and chemoresistance. A better understanding of the molecular basis of its drug resistance is needed. In this study, the first of its kind, the expression of both MDR1 P-gp and MRP-1 protein in pancreatic tumour specimens was examined by immunohistochemistry. Expression of these drug efflux pumps was examined using semi-quantitative immunohistochemistry according to the percentage of cells within the tumour, demonstrating another staining intencity. Overall, 93.3% of pancreatic carcinomas expressed MDR1 P-gp, approximately 31% co-expressed MRP-1 with MDR1 P-gp, while 6.7% expressed neither of these proteins. Our results show that drug efflux pumps, in particular that of MDR1 P-gp, are frequently expressed in pancreatic cancer. While a causative role for these efflux pumps in pancreatic cancer chemoresistance cannot necessarily be concluded, the information presented here should be considered when selecting chemotherapy/drug efflux pump inhibitors for future therapies.
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Full list of authors on original publication

S Kennedy, J Crown, M Clynes, R O'Connor, G Gullo, W S Ooi, J Ballot, A Larkin, N Walsh, L O'Driscoll

Experts in our system

1
Susan Kennedy
Dublin City University
Total Publications: 37
 
2
John Crown
Dublin City University
 
3
Martin Clynes
Dublin City University
Total Publications: 209
 
4
Robert O'Connor
Dublin City University
Total Publications: 71
 
5
Annemarie Larkin
Dublin City University
Total Publications: 25
 
6
Naomi Walsh
Dublin City University
Total Publications: 18
 
7
Lorraine O'Driscoll
Trinity College Dublin
Total Publications: 152