Type

Journal Article

Authors

Richard O'Kennedy
Gerard G. Donohoe
Barry Byrne

Subjects

Microbiology

Topics
eukaryotic cells animals molecular structure chemistry immunology metabolism pharmaceutical preparations drug industry sialic acids therapeutic use drug design prokaryotic cells humans glycoproteins

Sialic acids: carbohydrate moieties that influence the biological and physical properties of biopharmaceutical proteins and living cells. (2006)

Abstract Sialic acids are structurally diverse molecules that have important roles in the physiological reactions and characteristics of prokaryotes and eukaryotes. These include the ability to mask epitopes on underlying glycan chains and to repulse negatively charged moieties. Here, we describe the metabolism and immunological relevance of sialic acids and outline how their properties have been exploited by the pharmaceutical industry to enhance the therapeutic properties of proteins such as asparaginase and darbepoetin alpha.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Richard O'Kennedy, Gerard G. Donohoe, Barry Byrne

Experts in our system

1
R O'Kennedy
Dublin City University
Total Publications: 197
 
2
Barry Byrne
Dublin City University
Total Publications: 15