Type

Journal Article

Authors

Martin Clynes
John Crown
Giuseppe Gullo
Wei Ooi
Jo Ballot
Lisa Connolly
Susan Kennedy
Annemarie Larkin
Lorraine O'Driscoll
Naomi Walsh

Subjects

Microbiology

Topics
mrp 1 1 protein biomarkers tumor pharmacy and pharmaceutical sciences tumor cells cultured aged 80 and over p glycoproteins kidney neoplasms administration dosage multidrug resistance associated proteins abcb1 protein human neoplasm proteins humans p glycoprotein drug effects high frequency protein expression p gp female multidrug resistance metabolism antineoplastic agents male multidrug resistance associated protein 1 drug therapy aged cancer carcinoma renal cell middle aged tumor markers biological gene expression regulation neoplastic

Expression of multidrug resistance markers ABCB1 (MDR-1/ Pgp) and ABCC1 (MRP-1) in renal cell carcinoma (2009)

Abstract Background Renal cell carcinoma patients respond poorly to conventional chemotherapy, this unresponsiveness may be attributable to multidrug resistance (MDR). The mechanisms of MDR in renal cancer are not fully understood and the specific contribution of ABC transporter proteins which have been implicated in the chemoresistance of various cancers has not been fully defined in this disease. Methods In this retrospective study the expression of two of these transporter efflux pumps, namely MDR-1 P-gp (ABCB1) and MRP-1 (ABCC1) were studied by immunohistochemistry in archival material from 95 renal cell carcinoma patients. Results In the first study investigating MDR-1 P-gp and MRP-1 protein expression patterns in renal cell carcinoma patients, high levels of expression of both efflux pumps are observed with 100% of tumours studied showing MDR-1 P-gp and MRP-1 positivity. Conclusion Although these findings do not prove a causal role, the high frequency of tumours expressing these efflux pumps suggests that they may be important contributors to the chemoresistance of this tumour type.
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Full list of authors on original publication

Martin Clynes, John Crown, Giuseppe Gullo, Wei Ooi, Jo Ballot, Lisa Connolly, Susan Kennedy, Annemarie Larkin, Lorraine O'Driscoll, Naomi Walsh

Experts in our system

1
Martin Clynes
Dublin City University
Total Publications: 209
 
2
John Crown
Dublin City University
 
3
Susan Kennedy
Dublin City University
Total Publications: 37
 
4
Annemarie Larkin
Dublin City University
Total Publications: 25
 
5
Lorraine O'Driscoll
Trinity College Dublin
Total Publications: 152
 
6
Naomi Walsh
Dublin City University
Total Publications: 18