Type

Journal Article

Authors

M Clynes
M Parkinson
N J O'Higgins
A D Hill
E W McDermott
K Scanlon
A Larkin
S Glynn
R Linehan
R Purcell
and 3 others

Subjects

Biochemistry

Topics
breast cancer breast neoplasms aged 80 and over expression aged biosynthesis adult neoplasm staging pathology disease free survival relevance metabolism rna messenger humans middle aged prognostic myeloid cell leukemia sequence 1 protein immunohistochemistry proto oncogene proteins c bcl 2 female neoplasm proteins genetics

Expression and prognostic relevance of Mcl-1 in breast cancer. (2004)

Abstract Bcl-2, an anti-apoptotic protein, is frequently associated with favourable prognosis in breast cancer. The potential role of mcl-1, another bcl-2 family member, in breast cancer has not yet been defined. This study examined the expression of mcl-1 and bcl-2 in 170 cases of invasive primary breast carcinoma, using reverse-transcriptase polymerase chain reaction and immunohistochemical analyses. Expression of bcl-2 mRNA and protein were found to be favourably associated with outcome for patients, supporting a prognostic role for bcl-2 in breast cancer, whereas mcl-1 expression, at the mRNA or protein level, did not correlate with tumour size, grade, lymph node or ER status, age of patient at diagnosis, or disease outcome. As these analyses of mcl-1 expression may have co-detected mcl-1(S/deltaTM) (a more recently identified, shorter variant, that may be pro-apoptotic) with the anti-apoptotic wild-type of mcl-1, it is possible that future studies may indicate some significant clinical correlations if the isoforms can be independently investigated.
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Full list of authors on original publication

M Clynes, M Parkinson, N J O'Higgins, A D Hill, E W McDermott, K Scanlon, A Larkin, S Glynn, R Linehan, R Purcell and 3 others

Experts in our system

1
Martin Clynes
Dublin City University
Total Publications: 209
 
2
Arnold D K Hill
Royal College of Surgeons in Ireland
Total Publications: 109
 
3
E W McDermott
University College Dublin
Total Publications: 47
 
4
Annemarie Larkin
Dublin City University
Total Publications: 25
 
5
Sharon A Glynn
National University of Ireland Galway
Total Publications: 21