Type

Journal Article

Authors

Martin Clynes
Michael Parkinson
Niall J O'Higgins
Arnold D Hill
Enda W McDermott
Sharon Glynn
Rachel Purcell
Deirdre Cronin
Susan M Kennedy
Rasha Linehan
and 1 others

Subjects

Biochemistry

Topics
bcl2 associated athanogene 1 protein proto oncogene proteins c bcl 2 neoplasm invasiveness chemokines cc survival rate bcl 2 associated x protein dna primers aged middle aged transcription factors tumor markers biological significance gene expression regulation neoplastic rna neoplasm microtubule associated proteins carrier proteins breast neoplasms mrp 1 prognosis aged 80 and over breast cancer alpha dna binding proteins inhibitor of apoptosis proteins bax protein human rna messenger carcinoma lobular prognostic carcinoma ductal adult birc5 protein human metabolism humans neoplasm proteins galectin 3 reverse transcriptase polymerase chain reaction proto oncogene proteins female survivin antigens neoplasm chemistry genetics galectin 1 pathology ccl6 protein mouse

Lack of prognostic significance of survivin, survivin-deltaEx3, survivin-2B, galectin-3, bag-1, bax-alpha and MRP-1 mRNAs in breast cancer. (2003)

Abstract The expression of transcripts for anti-apoptotic (survivin, survivin-deltaEx3, survivin-2B, galectin-3, bag-1 and bcl-2) and pro-apoptotic (bax-alpha) genes, and for multiple drug resistance related protein-1 (MRP-1) gene were investigated, using RT-PCR, in 106 breast tumour biopsies. Normal breast tissue was also analysed for comparative purposes. Overall, survivin, survivin-deltaEx3, survivin-2B, bcl-2, bag-1, galectin-3, bax-alpha and MRP-1 mRNAs were detected in 68, 54.7, 9.4, 78.4, 80.9, 98.9, 97.8 and 72.8%, respectively, of tumour specimens. Uniquely among the mRNAs analysed, the expression of bcl-2 correlated significantly with disease outcome, with bcl-2 expression indicative of favourable outcome in terms of both relapse-free survival and overall survival. This suggests that bcl-2 mRNA expression may be a key prognostic marker for breast cancer and that routine analysis of expression of this transcript should be considered. The results from this study suggest, however, that the expression of survivin, survivin-deltaEx3, survivin-2B, bag-1, galectin-3, bax-alpha and MRP-1 mRNAs cannot be considered as prognostic indicators of disease outcome for patients with breast cancer.
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Full list of authors on original publication

Martin Clynes, Michael Parkinson, Niall J O'Higgins, Arnold D Hill, Enda W McDermott, Sharon Glynn, Rachel Purcell, Deirdre Cronin, Susan M Kennedy, Rasha Linehan and 1 others

Experts in our system

1
Martin Clynes
Dublin City University
Total Publications: 209
 
2
Sharon A Glynn
National University of Ireland Galway
Total Publications: 21
 
3
Susan Kennedy
Dublin City University
Total Publications: 37