Type

Journal Article

Authors

M Clynes
K Scanlon
N Daly
L O'Driscoll
S McBride
S Coyle
C Daly

Subjects

Biochemistry

Topics
tumor cells cultured substrate specificity rna messenger cell lines rna catalytic lung neoplasms codon plasmids base sequence transfection polymerase chain reaction neoplasm proteins rna neoplasm lung p glycoprotein drug effects humans antineoplastic agents phytogenic toxicity exons carcinoma squamous cell doxorubicin human genetics metabolism phenotype gene expression regulation neoplastic vincristine drug drug resistance neoplasm antibiotics antineoplastic pathology etoposide drug resistance multiple rna antisense pharmacology

mdr1 ribozyme mediated reversal of the multi-drug resistant phenotype in human lung cell lines. (1996)

Abstract An mdr1 hammerhead was introduced into two adriamycin-selected multi-drug resistant human lung cell lines both of which over-express p-glycoprotein. Expression of the ribozyme resulted in a decrease in mdr1 mRNA expression and an increase in drug sensitivity in both cell lines. This would suggest that the use of specific ribozymes may represent an effective and specific approach in order to restore cellular sensitivity towards anti-cancer drugs.
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Full list of authors on original publication

M Clynes, K Scanlon, N Daly, L O'Driscoll, S McBride, S Coyle, C Daly

Experts in our system

1
Martin Clynes
Dublin City University
Total Publications: 209
 
2
Lorraine O'Driscoll
Trinity College Dublin
Total Publications: 152
 
3
Shirley Coyle
Dublin City University
Total Publications: 86
 
4
C Daly
Trinity College Dublin
Total Publications: 15