Type

Journal Article

Authors

R O'Kennedy
D A Egan

Subjects

Microbiology

Topics
humans coumarin umbelliferones glucuronates urine chromatography high pressure liquid hydrolysis administration dosage blood administration oral coumarins

Rapid and sensitive determination of coumarin and 7-hydroxycoumarin and its glucuronide conjugate in urine and plasma by high-performance liquid chromatography. (1992)

Abstract A rapid and sensitive high-performance liquid chromatographic method was developed for the analysis of coumarin, 7-hydroxycoumarin and its glucuronide conjugate in urine and plasma. This method was used to monitor the urinary excretion of these compounds following a single oral dose of coumarin (100 mg). This new method gives excellent chromatographic separation and includes an internal standard. The method was validated and shown to be both accurate and precise in the range 0.5-100 micrograms/ml.
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Full list of authors on original publication

R O'Kennedy, D A Egan

Experts in our system

1
R O'Kennedy
Dublin City University
Total Publications: 197
 
2
Denise A Egan
IT Tallaght
Total Publications: 44