Journal Article


P Roben
R O'Kennedy



humans antibodies monoclonal antibody diversity chemistry polymerase chain reaction cloning molecular genetic engineering molecular structure antibodies animals genetics

Antibody engineering: an overview. (1991)

Abstract We can now isolate and manipulate antibody genes. Mouse antibodies can be humanized, resulting in chimaeric or reshaped antibodies. Antibody engineering is useful in large scale production of antibodies, in production of active antibody fragments, bifunctional, single-domain and catalytic antibodies, and has lead to the production of novel expression systems useful in many other areas. It allows production of new antibody conjugates, e.g. antibody-toxin or antibody-enzyme linked proteins. Engineered antibodies have many potential applications e.g. imaging, therapy and biosensors.
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Full list of authors on original publication

P Roben, R O'Kennedy

Experts in our system

R O'Kennedy
Dublin City University
Total Publications: 197