Type

Journal Article

Authors

John Crown
Martin Clynes
Guisipi Gullo
Wei Ooi
Jo Ballot
Denis Collins
Irene Oglesby
Catherine Conway
Thamir Mahgoub
Alex Eustace
and 6 others

Subjects

Medicine & Nursing

Topics
female mrp 1 oncology pathology mdr1 p gp multidrug resistance associated proteins male multidrug resistance associated protein 1 membrane transport proteins retrospective studies cancer efflux pumps neoplasm invasiveness malignant melanoma melanoma multiple drug resistance middle aged neoplasm metastasis metabolism humans drug resistance neoplasm p glycoprotein immunohistochemistry

Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis (2010)

Abstract Background: Malignant melanoma, generally described as incurable, is notoriously refractory to chemotherapy. The mechanisms contributing to this have not yet been defined and the contributions of drug efflux pumps, implicated in chemo-resistance of many other cancer types, have not been extensively investigated in melanoma. Methods: In this study, expression of multi-drug resistant (MDR1/P-gp and MRP-1) proteins was examined, by immunohistochemistry, in archival specimens from 134 melanoma patients. This included 92 primary tumours and 42 metastases. Results: On assessing all specimens, MRP-1 and MDR1/P-gp expression was found to be common, with the majority (81%) of melanomas expressing at least one of these efflux pumps. Although there is significant association between expression of these pumps (P=0.007), MRP-1 was found to be the predominant (67% of cases) form detected. ?2 analysis showed significant associations between expression of MRP-1 and/or MDR1/P-gp and the aggressive nature of this disease specifically increased Breslow's depth, Clark's level and spread to lymph nodes. This association with aggressiveness and spread is further supported by the observation that a significantly higher percentage of metastases, than primary tumours, express MRP-1 (91% vs 57%; P<0.0001) and MDR1/P-gp (74% vs 50%; P=0.010). Conclusion: The predominant expression of these pumps and, in particular, MRP-1 suggests that they may be important contributors to the inherent aggressive and resistant nature of malignant melanoma.
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Full list of authors on original publication

John Crown, Martin Clynes, Guisipi Gullo, Wei Ooi, Jo Ballot, Denis Collins, Irene Oglesby, Catherine Conway, Thamir Mahgoub, Alex Eustace and 6 others

Experts in our system

1
John Crown
Dublin City University
 
2
Martin Clynes
Dublin City University
Total Publications: 209
 
3
D M Collins
Dublin City University
Total Publications: 16
 
4
Irene K Oglesby
Royal College of Surgeons in Ireland
Total Publications: 13
 
5
Thamir Mahgoub
Dublin City University
Total Publications: 6
 
6
Alex J Eustace
Royal College of Surgeons in Ireland
Total Publications: 23