Journal Article


Eoin O'Brien
Seamus Sreenan
John H McDermott
Tommy Kyaw Tun
Lelane van der Poel
Eamon Dolan
Mohd S Draman


Medicine & Nursing

cardiovascular risk proportional hazards blood pressure 5 years cardiovascular mortality time pressure cox model follow up

The importance of night-time systolic blood pressure in diabetic patients: Dublin Outcome Study. (2015)

Abstract Diabetic patients exhibit a higher cardiovascular risk compared to people without diabetes. The use of ambulatory blood pressure monitoring (ABPM) is gaining popularity in this population. Night-time SBP has consistently been shown to be a potent predictor of cardiovascular risk in the normal population. We studied the predictive value of night-time ABPM in a cohort of diabetic patients. At baseline, when not on antihypertensive medication, 11 291 patients (5326 men, mean age 54.6 years) underwent ABPM. Using a computerized national registry of death, mortality outcome was ascertained. Among 859 diabetic patients with a mean follow-up of 5.3 years, there were 74 deaths. Compared to people without diabetes, those with diabetes had daytime and night-time SBP of 146.4 vs. 145.1 (P = NS) and 131.2 vs. 126.4 mmHg (P < 0.0001), respectively. As a consequence, more diabetic patients had a non-dipping night-time SBP profile (47.4 vs. 35.5%; P =  < 0.0001). In a Cox proportional-hazards model, night-time SBP was an independent predictor of cardiovascular mortality in diabetic patients after adjustment for sex, age, smoking history, previous cardiovascular events, BMI and daytime SBP. The resultant hazard ratio for a 10-mmHg increase in night-time SBP for total cardiovascular, stroke and cardiac mortality was 1.32 (1.12-1.69), 1.95 (1.18-3.20) and 1.24 (0.99-1.56), respectively. Night-time SBP is a significant predictor of cardiovascular mortality in patients with diabetes.
Collections Ireland -> IT Blanchardstown -> PubMed

Full list of authors on original publication

Eoin O'Brien, Seamus Sreenan, John H McDermott, Tommy Kyaw Tun, Lelane van der Poel, Eamon Dolan, Mohd S Draman

Experts in our system

Eoin O'Brien
University College Dublin
Total Publications: 75
Seamus Sreenan
Royal College of Surgeons in Ireland
Total Publications: 35
J H McDermott
IT Blanchardstown
Total Publications: 13
Tommy Kyaw Tun
IT Blanchardstown
Total Publications: 3
Eamon Dolan
IT Blanchardstown
Total Publications: 42