Type

Journal Article

Authors

Liam Cormican
John Faul
Basil Elnazir
Conor P Kerley

Subjects

Medicine & Nursing

Topics
intervention studies vitamin d supplementation vitamin d vitamin d deficiency adverse effects two part risk factors pulmonary function

Vitamin D as an adjunctive therapy in asthma. Part 2: A review of human studies. (2015)

Abstract Vitamin D deficiency (VDD) is highly prevalent worldwide, with adverse effects on bone health but also potentially other unfavorable consequences. VDD and asthma-incidence/severity share many common risk factors, including winter season, industrialization, poor diet, obesity, dark skin pigmentation, and high latitude. Multiple anatomical areas relevant to asthma contain both the enzyme responsible for producing activated vitamin D and the vitamin D receptor suggesting that activated vitamin D (1,25-dihydroxyvitamin D) may have important local effects at these sites. Emerging evidence suggests that VDD is associated with increased airway hyperresponsiveness, decreased pulmonary function, worse asthma control, and possibly decreased response to standard anti-asthma therapy. However the effect is inconsistent with preliminary evidence from different studies suggesting vitamin D is both beneficial and detrimental to asthma genesis and severity. Current evidence suggests that supplementation with moderate doses of vitamin D may be appropriate for maintenance of bone health in asthmatics, particularly steroid users. However emerging data from an increasing number of randomized, controlled, intervention studies of vitamin D supplementation in pediatric and adult asthma are becoming available and should help determine the importance, if any of vitamin D for asthma pathogenesis. The purpose of this second of a two-part review is to review the current human literature on vitamin D and asthma, discussing the possible consequences of VDD for asthma and the potential for vitamin D repletion as adjunct therapy.
Collections Ireland -> IT Blanchardstown -> PubMed

Full list of authors on original publication

Liam Cormican, John Faul, Basil Elnazir, Conor P Kerley

Experts in our system

1
Liam Cormican
IT Blanchardstown
 
2
John Faul
IT Blanchardstown
Total Publications: 11
 
3
B Elnazir
IT Tallaght
Total Publications: 14
 
4
Conor P Kerley
IT Blanchardstown