Type

Other / n/a

Authors

Liam Cormican
John Faul
Basil Elnazir
Conor P Kerley

Subjects

Veterinary

Topics
vitamin d muscle function t cells vitamin d deficiency gastrointestinal tract antimicrobial peptides risk factors bacterial infections

Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms. (2014)

Abstract Vitamin D deficiency (VDD) is highly prevalent worldwide. The classical role for vitamin D is to regulate calcium absorption form the gastrointestinal tract and influence bone health. Recently vitamin D receptors and vitamin D metabolic enzymes have been discovered in numerous sites systemically supporting diverse extra-skeletal roles of vitamin D, for example in asthmatic disease. Further, VDD and asthma share several common risk factors including high latitude, winter season, industrialization, poor diet, obesity, and dark skin pigmentation. Vitamin D has been demonstrated to possess potent immunomodulatory effects, including effects on T cells and B cells as well as increasing production of antimicrobial peptides (e.g. cathelicidin). This immunomodulation may lead to asthma specific clinical benefits in terms of decreased bacterial/viral infections, altered airway smooth muscle-remodeling and -function as well as modulation of response to standard anti-asthma therapy (e.g. glucocorticoids and immunotherapy). Thus, vitamin D and its deficiency have a number of biological effects that are potentially important in altering the course of disease pathogenesis and severity in asthma. The purpose of this first of a two-part review is to review potential mechanisms whereby altering vitamin D status may influence asthmatic disease.
Collections Ireland -> IT Blanchardstown -> PubMed

Full list of authors on original publication

Liam Cormican, John Faul, Basil Elnazir, Conor P Kerley

Experts in our system

1
Liam Cormican
IT Blanchardstown
 
2
John Faul
IT Blanchardstown
Total Publications: 11
 
3
B Elnazir
IT Tallaght
Total Publications: 14
 
4
Conor P Kerley
IT Blanchardstown