Type

Journal Article

Authors

Liam Cormican
John Faul
Conor Burke
Aisling McGowan
Kenneth Bolger
Kathleen Cahill
Conor P Kerley

Subjects

Pharmacology

Topics
acute randomized controlled trial blood pressure h 3 randomized controlled supplementation double blind peripheral vascular disease

Dietary nitrate supplementation in COPD: an acute, double-blind, randomized, placebo-controlled, crossover trial. (2014)

Abstract The acute consumption of dietary nitrate has been shown to improve exercise capacity in athletes, healthy adults and subjects with peripheral vascular disease. Many COPD patients have reduced exercise capacity. We hypothesized that acute nitrate consumption might increase incremental shuttle walk test (ISWT) distance in COPD subjects. Eleven COPD subjects were randomly assigned to consume either a high nitrate or a matched, low nitrate beverage in a double-blind, randomized, placebo-controlled, crossover design. ISWT distance was measured both before and 3 h after the beverage and change was recorded. After a 7-day washout, ISWT distances were re-measured before and 3 h after the alternate beverage and changes were recorded. We observed an increase in ISWT distance after consuming the high nitrate juice (25 m) compared with a reduction after the low nitrate juice (14 m) (p < 0.01). This improvement in exercise capacity was associated with significant increases in serum nitrate (p < 0.000005) and nitrite (p < 0.01) levels and a significant lowering of resting blood pressure (<0.05). In patients with stable COPD, the acute consumption of dietary nitrate increased serum nitrate/nitrite levels and exercise capacity and was associated with a decrease in resting blood pressure. Nitrate consumption might alter exercise capacity in COPD patients.
Collections Ireland -> IT Blanchardstown -> PubMed

Full list of authors on original publication

Liam Cormican, John Faul, Conor Burke, Aisling McGowan, Kenneth Bolger, Kathleen Cahill, Conor P Kerley

Experts in our system

1
Liam Cormican
IT Blanchardstown
 
2
John Faul
IT Blanchardstown
Total Publications: 11
 
3
Aisling McGowan
IT Blanchardstown
Total Publications: 3
 
4
Conor P Kerley
IT Blanchardstown